Anti-CD11b/c equivalent整合素αM抗体Integrin αM抗体相关标记     Alexa Fluor 350   Alexa Fluor 488   Alexa Fluor 555   Alexa Fluor 647   AP   APC   Biotin   Cy3   Cy5  
 Cy5.5   Cy7   FITC   Gold   HRP   PE   PE-Cy3   PE-CY5   PE-CY5.5   PE-CY7   RBITC  
英文名称     Anti-CD11b/c equivalent
中文名称     整合素αM抗体Integrin αM
别    名     Antigen CD11b (p170); CD11 antigen like family member B; CD11 antigen like family member C; CD11B; CD11C; Cell surface glycoprotein MAC 1 subunit alpha; CR 3 alpha chain; CR3A; Integrin alpha M; Integrin alpha X; Integrin, alpha M (complement component 3 receptor 3 subunit); Integrin, alpha X (antigen CD11C (p150), alpha polypeptide); Integrin, alpha X (complement component 3 receptor 4 subunit); ITGAM; ITGAX; Leu M5, alpha subunit; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor MO1; Leukocyte adhesion receptor p150,95; Leukocyte surface antigen p150,95, alpha subunit; MAC1A; Macrophage antigen alpha polypeptide; MO1A; Myeloid membrane antigen, alpha subunit; Neutrophil adherence receptor alpha M subunit; p150 95 integrin alpha chain; SLEB6; ITAM_HUMAN. 
抗体来源     Rabbit
克隆类型     polyclonal
交叉反应     Human, Mouse, Rat, Horse, 
产品类型     一抗  
研究领域     神经生物学 细胞粘附分子
蛋白分子量     predicted molecular weight: 125kDa
性    状     Lyophilized or Liquid
免 疫 原     KLH conjugated synthetic peptide derived from human CD11b
亚    型     IgG
纯化方法     affinity purified by Protein A
储 存 液     Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
 Anti-CD11b/c equivalent整合素αM抗体Integrin αM抗体产品应用      WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  Flow-Cyt=1:100-500  ICC=1:100-500  IF=1:100-500 
（石蜡切片需做抗原修复） 

 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user.
保存条件     Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
 Anti-CD11b/c equivalent整合素αM抗体Integrin αM抗体产品介绍    CD11b is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement coated particles. It is identical to CR3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the RGD peptide in C3b. CD11b is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. The Mac1 CD11b antigen is present on macrophages, granulocytes, natural killer cells, blood monocytes. CD11b is expressed on 8% spleen cells, 44% bone marrow cells and less than 1% of thymocytes and is commonly used as a microglial marker in nervous tissue. CD11c is aiIntegrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.
Function : Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. 
Subunit : Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2. Interacts with JAM3.
Subcellular Location : Plasma membrane
Tissue Specificity : Predominantly expressed in monocytes and granulocytes.
DISEASE : Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:609939]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
Similarity : Belongs to the integrin alpha chain family. 
Contains 7 FG-GAP repeats. 
Contains 1 VWFA domain. 
Database links : UniProtKB/Swiss-Prot: P11215.2