Description
Biochem/physiol Actions Phosphodiesterase inhibitor; diuretic; cardiac stimulant; muscle relaxant; asthma medication.

Properties
grade anhydrous
assay ≥98%
form powder
color white
solubility 0.1 M HCl: soluble
  0.1 M NaOH: soluble
  H2O: slightly soluble
  ethanol: moderay soluble
Gene Information human ... ADORA1（134）, ADORA2A（135）, ADORA2B（136）, ADORA3（140）, PDE3A（5139）, PDE4B（5142）
  rat ... Adora1（29290）, Adora2a（25369）, Adora2b（29316）, Pde1b（29691）, Pde3a（50678）
  mouse ... Adora2b（11541）

Safety
Personal Protective Equipment dust mask type N95 （US）, Eyeshields, Faceshields, Gloves
Hazard Codes Xn
Risk Statements 22
RIDADR UN2811 6.1/PG 3
WGK Germany 1
RTECS XH3850000

References
reference Reuter, et al., Phosphodiesterase inhibitors prevent NSAID enteropathy independently of effects on TNF-alpha release. Am. J. Physiol. 277, G8478-G8454, （1999）
  Linden, et al., Characterization of human A（2B） adenosine receptors: radioligand binding, western blotting, and coupling to G（q） in human embryonic kidney 293 cells and HMC-1 mast cells. Mol. Pharmacol. 56, 705-713, （1999）
  Giri, et al., Mutagenic and genotoxic effects of theophylline and theobromine in Salmonella assay and in vivo sister chromatid exchanges in bone marrow cells of mice. Mutat. Res. 444, 17-23, （1999）
Merck Merck 13,9356
Beilstein Beil. 26,IV,2331

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