Cat. Number:  Rs-1424R

Quantity size:  0.1ml （dilute with pH 7.4    0.01 M PBS or diluent of antibody）

 

Background: The erythropoietin receptor （EPOR） is a member of the cytokine receptor family. There are several isoforms including: EPOR-F （full length）, EPOR-S （soluble form）, and EPOR-T （truncated form）. Upon erythropoietin （EPO） binding, the EPOR activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated EPOR appears to have a role in erythroid cell survival. Defects in the EPOR may produce erythroleukemia and familial erythrocytosis. A functional EPOR is found in the cardiovascular system, including endothelial cells and cardiomyocytes, and data suggest that the EPO/EPO receptor system plays an important role in cardiac function. In animal studies, treatment with EPO during ischemia/reperfusion in the heart has been shown to limit the infarct size and the extent of apoptosis.

 

Specificity:       ·anti-EPOR is a rabbit monoclonal antibody unconjugated

                ·specific for EPOR of  hu, rat and mo 

· Protein A affinity chromatography purification, purity :>95%

· Isotype: IgG

· mol wt: 82kDa

 

Application:     · Western blotting: 1:100-500

· Immunohistochemistry: 1:100-500

· ELISA: 1:500-1000

· Optimal working dilutions must be determined by the end user.

 

 

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.