链脲佐菌素

分类 蛋白质

级别 优级纯GR

含量 ≥98（％）

产品规格 SIGMA S0130-5G

CAS   18883-66-4

品牌 sigma

用途范围 生物科研

保存温度 -20℃

英文名称 Streptozocin STZ

供应商    上海研伴实业有限公司

 链脲佐菌素      SIGMAS0130-5G

≥75% α-anomer basis, ≥98% (HPLC), powder

· 产品编号：S0130

· 中文名称：

· 英文名称：Streptozocin STZ

· CAS号：18883-66-4

· 分子式：C8H15N3O7

· 分子量：265.22

· 纯度：≥98%

· 保存温度：−20 °C

· EC号：242-646-8

· MDL号：MFCD00006607

订货信息：

产品规格价格(RMB)

· S0130-100MG   电仪/元

· S0130-500MG    电仪/元

· S0130-1G     电仪/元

· S0130-5G    电仪/元

注：此价格仅供参考，不作为成交价格，请以SIGMA价格为准。

性能描述

Application

Streptozocin is used to induce Type 1 diabetes for medical research.

General description

Streptozotocin, a glucosamine-nitrosourea, is a DNA alkylating agent that enters cells exclusively via the GLUT2 glucose transport protein. Streptozocin, a diabetagen, is especially toxic to pancreatic islet insulin-producing β-cells. It is toxic to GLUT2 positive neuroendocrine tumor cells.

Biochem/physiol Actions

An N-nitroso-containing compound that acts as a nitric oxide donor in pancreatic islets; induces death of insulin-secreting cells, producing an animal model of diabetes. Potent DNA methylating agent that induces chromosomal breakage.1 Cytotoxic to neuroendocrine tumor cell lines that express the GLUT2 glucose transporter.

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