品牌
代理商厂商性质
上海市所在地
| Catalogue Number | CYT-363 | |
| Synonyms | Melanoma differentiation association like protein, MDA1, NG.1, ZMDA1, IL-10C, IL-19. | |
| Introduction | IL19 is a cytokine that belongs to the IL10 cytokine subfamily. IL-19 is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 （STAT3）. A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described. | |
| Description | Interleukin-19 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 155 amino acids and having a molecular mass of 17913 Dalton. The IL-19 is purified by proprietary chromatographic techniques. | |
| Source | Escherichia Coli. | |
| Physical Appearance | Sterile Filtered White lyophilized （freeze-dried） powder. | |
| Formulation | Lyophilized from a concentrated （1mg/ml） solution in water containing 10mM sodium citrate pH-5. | |
| Solubility | It is recommended to reconstitute the lyophilized Interleukin -19 in sterile 18MΩ-cm H2O at a concentration of 0.5mg/ml or less. | |
| Stability | Lyophilized Interleukin-19 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL19 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles. | |
| Purity | Greater than 99.0% as determined by（a） Analysis by RP-HPLC. （b） Analysis by SDS-PAGE. | |
| Amino acid sequence | The sequence of the first five N-terminal amino acids was determined and was found to be Met-Leu-Arg-Arg-Cys. | |
| Biological Activity | The activity is determined by it's ability to activate STAT following receptor-ligand interaction. | |
| Usage | ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. | |
| Related Products |
|
