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上海市所在地
| Catalogue Number | CYT-347 | |
| Synonyms | IL10D, ZCYTO10, IL-20, MGC96907, Four alpha helix cytokine Zcyto10. | |
| Introduction | IL20 is a cytokine structurally related to interleukin 10 （IL10）. IL20 cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 （STAT3） in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis. | |
| Description | Interleukin-20 Human Recombinant produced in E.Coli is a single, non-glycosylated homodimeric polypeptide chain containing 2 x 153 amino acids and having a total molecular mass of 35,212 Dalton. The IL-20 is purified by proprietary chromatographic techniques. | |
| Source | Escherichia Coli. | |
| Physical Appearance | Sterile Filtered White lyophilized （freeze-dried） powder. | |
| Formulation | Lyophilized carrier free. | |
| Solubility | It is recommended to reconstitute the lyophilized Interleukin -20 in sterile 18MΩ-cm H2O at a concentration of 0.5mg/ml or less. | |
| Stability | Lyophilized Interleukin-20 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL20 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles. | |
| Purity | Greater than 95.0% as determined by（a） Analysis by RP-HPLC. （b） Analysis by SDS-PAGE. | |
| Amino acid sequence | The sequence of the first five N-terminal amino acids was determined and was found to be Met-Leu-Lys-Thr-Leu. | |
| Biological Activity | The Biological Activity was determined by measuring the dose dependent activation of STAT3 in human epidermal keratinocytes （HEKa cells）.Significant STAT3 activation is observed with 100 ng/mL of recombinant human IL-20 corresponding to a Specific Activity of 10,000IU/mg. | |
| Usage | ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. | |
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