中文名称：白细胞介素-7受体a抗体

英文名称：Anti-IL-7Ra

产品编号：BYK-1540R

别名：COP9 Complex Homolog Subunit 7b; COP9 Constitutive Photomorphogenic Homolog Subunit 7b; COP9 Signalasome Subunit 7b; COP9 signalosome complex subunit 7b; COPS7B; CSN7B_HUMAN; JAB1 Containing Signalosome Subunit 7b; JAB1-containing signalosome subunit 7b; SGN7b; Signalosome subunit 7b.                                                                       

产品介绍：The COP9 signalosome (CSN) complex is involved in several different developmental and cellular processes. The complex is made up of several widely expressed proteins: CSN1 (COPS1), CSN2 (COPS2), CSN3 (COPS3), CSN4 (COPS4), CSN5 (COPS5), CSN6 (COP6), CSN7a (COPS7, COPS7a) or CSN7b (COP7b) and CSN8 (COP8). The CSN complex acts as a regulator for the ubiquitin conjugation pathway by mediating the deneddylation of the SCF-type E3 ligase complexes, which leads to a decrease in ubiquitin ligase activity of SCF-complexes. It is also involved in the phosphorylation of p53, c-Jun, I?Bå and IRF-8, as well as CSN-dependent phosphorylation of p53, and c-Jun protects and promotes degradation by the Ubl system. CSN7 is phosphorylated by CK2 and is composed of two subunits; a and b. CSN7a contains a PCI (Proteasome CSN9 initiation factor 3) region, as well as a coiled-coil region and is predicted to interact with CSN2, CSN3, CSN4, CSN5, CSN6, CSN8, and GPS1. CSN7b contains only a PCI region and is predicted to interact with INT6.

此产品本公司有标记的一抗出售，相关标记有：Alexa Fluor 350 标记、Alexa Fluor 488 标记、Alexa Fluor 555 标记、Alexa Fluor 647 标记、AP标记、APC标记、Biotin标记、Cy3标记、Cy5标记、Cy5.5标记、Cy7标记、FITC标记、Gold标记、HRP标记、PE标记、PE-Cy3标记、PE-CY5标记、PE-CY5.5标记、PE-CY7标记、RBITC标记

规格：0.1ml/0.2ml

浓度：1mg/1ml

抗体来源：本公司抗体有兔来源和鼠来源等

克隆类型：兔来源为多抗，鼠来源为单抗

产品类型：一抗

IL-7Ra抗体-白细胞介素-7受体a抗体保存条件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

避免反复冻融，保质期一年。

IL-7Ra抗体-白细胞介素-7受体a抗体对研究人员的多肽设计提供一些建议：

一、变难为易

1、减少序列长度

肽的长度增加导致粗产物纯度降低，小于15个残基的肽较容易得到.当肽链增加到20个以上时，正常产物的量就要考虑。在具体实践中残基低于20往往能得到更好的结果；

2、减少疏水残基

疏水残基占明显优势的肽，尤其在距C端7―12个残基的区域，会引起合成困难，一般认为由于合成中形成β折叠片，而产生不*配对。当然，可用几个极性残基置换，或加入Gly或Pro易打开肽结构可能会得到帮助；

3、减少“难度”残基

有多个Cys、Met、Arg、Try残基一般难以合成，Ser通常可作为非氧化替换。

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