鼠爪压力测痛仪（小鼠压痛仪，压力疼痛测试仪，Randall Selitto Paw Pressure Test Apparatus Mice and Rats）（测量并记录动物产生逃避反应时的瞬间压力，以测定动物机械钝痛的痛觉阈限，操作简便，更多详情敬请）

型号2500型

Randall&Selitto测试，通过逐步提高作用于动物爪子上的机械压力，逼近动物的疼痛阈限，测量并记录动物产生逃避反应时的瞬间压力，以测定动物机械钝痛的痛觉阈限。

与热痛不同，鼠爪压力疼痛测痛仪用于机械压痛和钝痛的痛觉测量，常用于辨别左右爪不同的痛觉反应，多涉及脊髓神经过程，人工辨别动物缩腿反应，并用踏板控制马达的起止。

Once again it has benn designed a first in the pain testing research field, the very first digitally controlled paw pressure meter. The unit allows the user to attain data for analgesic drug testing via the Randall Selitto method.

This hand held instrument applies a force to the extremity of the test subjects. “Live” readings are provided of whatever force is applied at any moment with “Peak and Hold” showing the last maximum force applied during the test. Additional “Pressure Applicators” available.

鼠爪压力疼痛测试仪主要特点 

Ø 适用于大鼠和小鼠

Ø 精确度为0.1克，压力400克

Ø 数字显示功能

Ø 配置脚踏控制器

Ø RS-232输出

 鼠爪压力疼痛测试仪型号参数

部分参考文献

Recombinant human lactoferrin prevents NSAID‐induced intestinal bleeding in rodents

EJ Dial, AJ Dohrman, JJ Romero… - Journal of pharmacy …, 2005 - Wiley Online Library

... two hours the rats were placed in a Randall-Sellito appa- ratus (IITC Inc., Woodlａnd Hills, CA ...
indometacin (10mgkgÀ1) or RHLF plus indometacin and tested for sensitivity to pressure/pain
on ... P<0.05 vs saline control inflamed paw; #P<0.05 vs saline control non-inflamed paw. ...

[HTML] High-fat diet-induced neuropathy of prediabetes and obesity: effect of PMI-5011, an ethanolic extract of Artemisia dracunculus L.

P Watcho, R Stavniichuk, DM Ribnicky… - Mediators of …, 2010 -

Hindawi Publishing Corporation. ... 2 Temperature Controller with RET-3 Temperature probe and
HL-1, Heat Lamp (Physitemp Instruments, Inc., Clifton, NJ ... A thermal stimulation meter (IITC model
336 TG Combination Tail Flick and Paw algesia meter, IITC Life Science, Woodland ...

Investigation of the anti-inflammatory, antinociceptive effect of ellagic acid as measured by digital paw pressure via the Randall-Selitto meter in male Sprague-Dawley …

J Gainok, R Daniels, D Golembiowski… - AANA …, 2011 -

... The Randall-Selitto IITC 2500 Digital Paw Pressure Meter (IITC Life Science Inc, Woodlａnd Hills ...
A single rat paw was stimu- lated with the Randall-Selitto IITC 2500, and a reading ... Ketorolac
(Syntax Corporation, Palo Alto, California) is a nonselective COX inhibitor tbat has been ...

[HTML] Analgesic effects of an ethanol extract of the fruits of Xylopia aethiopica (Dunal) A. Rich (Annonaceae) and the major constituent, xylopic acid in murine …

E Woode, EO Ameyaw, E Boakye-Gyasi… - Journal of pharmacy & …, 2012 - europepmc.org

... stimulus was measured with the radiant heat source method using the IITC Analgesia Meter
(Model 336, IITC Life Science Inc., Woodlａnd Hills ... paw pressure test, an inflammatory pain model,
widely used for quantification of thresholds of the rat hind paw withdrawal reflex to ...

[PDF] Characterization of a rat model of metastatic prostate cancer bone pain

PD De Ciantis, K Yashpal, J Henry, G Singh - J Pain Res, 2010 -

... An IITC Model 2500 Randall–Selitto Paw Pressure Meter (IITC Life Science Inc ... were fixed to a
microtome (Reichert-Jung 2040 Microtome; Reichert Inc., Depew, NY ... for each sample were recon-
structed with Cobra_EXXIM software (Exxim Computing Corporation, Pleasanton, CA ...

Randall-Selitto test: a new approach for the detection of neuropathic pain after spinal cord injury

E Santos-Nogueira, E Redondo Castro… - Journal of …, 2012 -

... by using the Randall-Selitto electronic algesimeter (IITC 2500 Digital Paw Pressure Meter, IITC
Life Science ... We therefore pooled right and left paw measurements to simplify statistical analyses. ...
The statistical software packages Statistica, v. 9 (StatSoft Inc., Tulsa, OH) and SPSS v ...

Anti-hyperalgesic and anti-allodynic activities of capillarisin via suppression of inflammatory signaling in animal model

S Khan, O Shehzad, J Chun, RJ Choi, S Park… - Journal of …, 2014 - Elsevier

... was evaluated at different time points (2, 4, and 6 h) using the Randall Selitto (Digital Paw
Pressure Randall Selitto Meter, IITC Life Science Inc). ... Briefly, paw skin tissues were removed
at the end of treatment, and total protein was extracted by using RIPA lysis buffer (Pierce ...

[HTML] The α7 nicotinic ACh receptor agonist compound B and positive allosteric modulator PNU‐120596 both alleviate inflammatory hyperalgesia and cytokine …

G Munro, RR Hansen, HK Erichsen… - British journal of …, 2012 - Wiley Online Library

... Immediately afterwards, the rat was gently restrained by the investigator before the application
of progressively increasing mechanical pressure to the mid-hind paw region using an electronic
version of the Randall-Selitto device (IITC Life Science Inc., Woodlａnd Hills ...

Peripheral Antinociception of a Chalcone, Flavokawin B and Possible Involvement of the Nitric Oxide/Cyclic Guanosine Monophosphate/Potassium Channels …

MN Kamaldin, MN Akhtar, AS Mohamad, N Lajis… - Molecules, 2013 -

... Ltd., China) to ensure complete dissolution of the chemicals. ... the right hind paw of the rat. The
mechanical nociceptive threshold was measured using a digital Randall Selitto paw pressure
test apparatus (Model 2500, IITC Life Science, Woodlａnd Hills, CA, USA). ...

Phagocytic microglial phenotype induced by glibenclamide improves functional recovery but worsens hyperalgesia after spinal cord injury in adult rats

E Redondo‐Castro, J Hernández… - European Journal of …, 2013 - Wiley Online Library

... 2013 Federation of European Neuroscience Societies and John Wiley & Sons Ltd. ... acclimated
to the belt compartment of a Digigait Imaging system (Mouse Specifics Inc., Boston, MA ... was
performed by means of a digital paw pressure meter device (IITC 2500, IITC Life Science ...

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