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| Catalogue Number | ENZ-112 | |
| Synonyms | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2, Alkylated DNA repair protein alkB homolog 2, Oxy DC1, ALKBH2, ABH2, FLJ99103, MGC90512. | |
| Introduction | ALKBH2 is a member of the ALKB family.ALKBH2 is expressed in the heart, colon, liver, testis, ovary, prostate and the small intestine. ALKBH2 uses iron as a cofactor and acts as a dioxygenase which catalyzes the repair of alkylated DNA and RNA containing 1-methyladenine and 3-meth-ylcytosine. ALKBH2 is functionally activated by ascorbate and requires oxygen and ?-ketoglutarate for enzymatic activity. | |
| Description | ALKBH2 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 281 amino acids （1-261 a.a.） and having a molecular mass of 31.4kDa. | |
| Source | Escherichia Coli. | |
| Physical Appearance | Sterile filtered colorless solution. | |
| Formulation | ALKBH2 solution （0.5mg/ml） containing 20mM Tris-HCl buffer （pH 8.0）, 1mM DTT and 30% glycerol. | |
| Amino acid sequence | MGSSHHHHHH SSGLVPRGSH MDRFLVKGAQ GGLLRKQEEQ EPTGEEPAVL GGDKESTRKR PRREAPGNGG HSAGPSWRHI RAEGLDCSYT VLFGKAEADE IFQELEKEVE YFTGALARVQ VFGKWHSVPR KQATYGDAGL TYTFSGLTLS PKPW*LER IRDHVSGVTG QTFNFVLINR YKDGCDHIGE HRDDERELAP GSPIASVSFG ACRDFVFRHK DSRGKSPSRR VAVVRLPLAH GSLLMMNHPT NTHWYHSLPV RKKVLAPRVN LTFRKILLTK K. | |
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Avoid multiple freeze-thaw cycles. | |
| Purity | Greater than 90.0% as determined by SDS-PAGE. | |
| Usage | ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. | |
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