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Human ALKBH2,重组人ALK 烷基化修复同系物2
面议
Human ALDOC,重组人果糖二磷酸醛缩酶A
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Human ALDOA,重组人醛缩酶A
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Human ALDH5A1,重组人醛脱氢酶3A1
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Human ALDH3A1,重组人醛脱氢酶3A1
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Human ALDH2,重组人醛脱氢酶2
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Human ALDH1A1,重组人醛脱氢酶1A1
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Human ALAT,重组人*转氨酶
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Human AKR7A3,重组人醛酮还原酶7-A3
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Human AKR7A2,重组人醛酮还原酶7-A2
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Human AKR1D1,重组人醛酮还原酶1-D1
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Human AKR1C4,重组人醛酮还原酶1-C4
面议| Catalogue Number | CHM-270 | ||
| Synonyms | C-C motif chemokine 17, Small-inducible cytokine A17, Thymus and activation-regulated chemokine, CC chemokine TARC, ABCD-2, CCL17, CCL-17, SCYA17, TARC, A-152E5.3, MGC138271, MGC138273. | ||
| Introduction | TARC cDNA encodes a 94 amino acid precursor protein with a 23 amino acid residue signal peptide that is cleaved off to generate the 71 amino acid residue mature secreted protein. Along with CC chemokine family members, CCL-17 has approximay 24-29% amino acid sequence identity with RANTES, MIP-1?, MIP-1?, MCP-1, MCP-2, MCP-3 and I-309. TARC is expressed in thymus, and at a lower level in the lung, colon, and small intestine. TARC is in addition transiently expressed in stimulated peripheral blood mononuclear cells. Recombinant TARC has been shown to be chemotactic for T cell lines but not monocytes or neutrophils. CCL-17 was recently identified to be a specific functional ligand for CCR4, a receptor that is selectively expressed on T cells. CCL17 is one of quite a few Cys-Cys （CC） cytokine genes clustered on the q arm of chromosome 16. CCL17 shows chemotactic activity for T lymphocytes, but not monocytes or granulocytes. CCL17 binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells. | ||
| Description | TARC Mouse Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 70 amino acids and having a molecular mass of 7.9kDa. The TARC Mouse is purified by proprietary chromatographic techniques. | ||
| Source | Escherichia Coli. | ||
| Physical Appearance | Sterile Filtered White lyophilized （freeze-dried） powder. | ||
| Formulation | The protein was lyophilized from a 0.2µm filtered concentrated solution in 1×PBS, pH7.4. | ||
| Solubility | It is recommended to reconstitute the lyophilized TARC in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. | ||
| Stability | Lyophilized TARC although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution TARC should be stored at 4C between 2-7 days and for future use below -18C. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles. | ||
| Purity | Greater than 97.0% as determined by （a） Analysis by RP-HPLC. （b） Analysis by SDS-PAGE. | ||
| Amino acid sequence | ARATNVGREC CLDYFKGAIP IRKLVSWYKT SVECSRDAIV FLTVQGKLIC ADPKDKHVKK AIRLVKNPRP | ||
| Biological Activity | Fully biologically active when compared to standard. The ED50 as determined by its ability to chemoattract BaF3 mouse pro-B cells transfected with human CCR4 is typically 2-10 ng/ml. | ||
| Usage | Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. | ||
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