200ug人α2微球蛋白|Human A2M|Human Alpha-2 Macroglobulin Protein
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上海市所在地
Human ALKBH2,重组人ALK 烷基化修复同系物2
面议Human ALDOC,重组人果糖二磷酸醛缩酶A
面议Human ALDOA,重组人醛缩酶A
面议Human ALDH5A1,重组人醛脱氢酶3A1
面议Human ALDH3A1,重组人醛脱氢酶3A1
面议Human ALDH2,重组人醛脱氢酶2
面议Human ALDH1A1,重组人醛脱氢酶1A1
面议Human ALAT,重组人*转氨酶
面议Human AKR7A3,重组人醛酮还原酶7-A3
面议Human AKR7A2,重组人醛酮还原酶7-A2
面议Human AKR1D1,重组人醛酮还原酶1-D1
面议Human AKR1C4,重组人醛酮还原酶1-C4
面议Synonyms | Alpha-2-macroglobulin, Alpha-2-M, A2M, CPAMD5, FWP007, S863-7, alpha 2M, DKFZp779B086. | |
Introduction | Alpha-2 Macroglobulin is a serine proteases inhibitor, which inhibits coagulation by inactivating thrombin and Kallikrein, it inhibits fibrinolysis by inactivating plasmin and involved in insulin transport. Alpha-2-Macroglobulin is a large plasma protein, which is produced by the liver, it’s composed of 4 identical subunits bound together by -S-S- bonds. A2M is able to inactivate many kinds of proteinases (including serine-, cysteine-, aspartic- and metalloproteinases). A2M has a 35 amino acid "bait" region in its structure. Proteinases bind and cleave the “bait” region become bound to A2M. Macrophage receptors recognize the proteinase-A2M complex and clear it from the system. A2M binds to and removes MMP-2 and MMP-9 (active forms of the gelatinase) from the circulation using scavenger receptors on the phagocytes. The levels of Alpha-2-macroglobulin are increased in nephrotic syndrome which is a condition where the kidneys start to leak out some of the smaller blood proteins. Due to its large size, A2-macroglobulin is retained in the bloodstream. Increased production of all proteins causes A2-macroglobulin concentration to increase. Chronic renal failure might lead to amyloid by alpha-2-macroglobulin. A2M is raised in cirrhosis, pregnancy and diabetes. | |
Description | Human Alpha-2 Macroglobulin is a tetrameric glycoprotein, produced in Human plasma and having a molecular mass of 725 kDa. | |
Source | Human Plasma. | |
Physical Appearance | Sterile Filtered White lyophilized (freeze-dried) powder. | |
Formulation | Lyophilized from 0.02M TRIS, 0.15M NaCl and 0.1M Sucrose, pH 8.0. | |
Solubility | It is recommended to reconstitute the lyophilized A2M in sterile 18MΩ-cm H2O. | |
Stability | Human Alpha-2 Macroglobulin although stable at room temperature for 3 weeks, should be stored between 2-8°C. Do not freeze! | |
Human Virus Test | Serum from each donor has been tested and found negative for antibody to HIV-1, HIV-2, HCV, HBSAG. | |
Purity | Greater than 96.0%. | |
Usage | Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. | |
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